We use the format of a hypothetical case study to review issues related to pharmaceutical product approval and physician prescribing practices. In this case, a new FDA-approved drug is recommended for a patient who subsequently experiences an adverse event that may or may not be related to the prescription. This case raises a number of ethical and legal considerations physicians routinely face when deciding whether to recommend such drugs for their patients. Despite the need for ongoing observation by the regulatory (...) apparatus, physicians should be cognizant of the limitations of the drug approval system and the post-approval prescription drug surveillance system. We discuss physicians’ ethical obligations when faced with a newly approved drug, including seeking out independent sources of learning, reporting adverse effects, and notifying patients about limitations in available knowledge about therapeutic recommendations. (shrink)

Isidore Etymologiae Vol. II. Books XI-XX.

Phage DNA packaging occurs by DNA translocation into a prohead. Terminases are enzymes which initiate DNA packaging by cutting the DNA concatemer, and they are closely fitted structurally to the portal vertex of the prohead to form a ‘packasome’. Analysis among a number of phages supports an active role of the terminases in coupling ATP hydrolysis to DNA translocation through the portal. In phage T4 the small terminase subunit promotes a sequence‐specific terminase gene amplification within the chromosome. This link between (...) recombination and packaging suggests a DNA synapsis mechanism by the terminase to control packaging initiation, formally homologous to eukaryotic chromosome segregation. (shrink)

Since Teuffel's Römische Literatur mentions s.v. Varius the famous entry in the Monte Cassino MS. incipit thvestes varii, but ignores its occurrence in a Benevento MS. , it may be well to give some account of the latter codex. For I read with amusement a recent article in this journal in which the writer severely censured Mr. Garrod's ignorance of the entry in Paris 7530, but revealed his own ignorance by assuming that it was the scribe of the Paris MS. (...) who had the lost tragedy of Varius before him. (shrink)

Lvcilivs 11191 is preserved for us in Isid. Etym. XIX, iv, 10, where, amongst the articles of a ship's equipment, the plummet of Herodotus is mentioned, with this illustration from Lucilius:Hunc catapiratem puer eodem deforet unctum,plumbi paucillum rudus linique mataxam.

The abbreviation-symbols of the Romans, found in ancient uncial MSS., may be roughly divided into three classes: Those peculiar to juristic writing, e.g. R.P. ‘res priuata’ , Q.D.R.A. ‘qua de re agitur.’ They are properly called ‘notae iuris.’ They abound in the famous Verona MS. of Gaius. A few used in histories, etc., e.g. R.P. 'respublica' , Q. ‘Quintus’ . Valerius Probus, who compiled a manual of ancient Notae, calls this class ‘notae publicae’. They appear in such MSS. as the (...) codex Puteanus of Livy ; and since they have been transferred into modern editions of the Latin historians, etc., no one is at a loss to interpret them nowadays, although they puzzled mediaeval scribes. Symbols of ordinary words of frequent occurrence in any type of literature, e.g. Q. ‘que.’ It is this class which is the subject of this article. (shrink)

Amph. prol. 90–91. In the Amphitruo Plautus runs great risk of giving oflence by bringing Jupiter on the stage. In the prologue he conciliates the audience by saying that this Jupiter is no god but a mere actor. : 26 sqq. Etenim ille quois hue iussu uenio Iuppiter Non minu' quam uostrum quiuis formidat malum: Humana matre natus, humano patre, Mirari non est aequom sibi si praetimet.

In the 'nineties the Celtic philologist, Whitley Stokes, told us in Common-room, that he once awoke muttering an incomplete stanza: Like an ogress making progress Through the spare-ribs of a child. Could anyone complete it for him ? A former Newdigate prizeman, after reflexion, produced this: Stern endeavour will be ever By some welcome find beguiled, Like an ogress making progress Through the spare-ribs of a child.

Mrs. Dall, in her article A Seventh-Century English Edition of Virgil , shows that Virgil glosses taken from marginalia in the same MS. of the poems often preserve something of their original coherence in the two kindred glossaries, Affatim and the Second Amplonian, in spite of all the reshuffling of these two collections. Thus a small group of Virgil items appears in Affatim on p. 491 of Goetz's apograph : Carecta, Crateras, etc. The second last of this ‘Virgil cluster’ is (...) Cada: vasa vinaria. It appears also in Ampl. II. Ca[t]da: vas vinaria, and in Ampl. I. Cada: vasa vinaria, and is apparently taken , ultimately or immediately, from a marginal annotation on Aen. 1, 195 ‘uina bonus quae deinde cadis onerarat Acestes’ for in the Virgil Glossary printed by Goetz in C.G.L. IV. 427–470 we find Cadis: vasis vinariis. (shrink)

In the Glossary-codex, Vat. Lat. 1469, written in the year 908, fol. 83 has been assigned to ‘glossae collectae.’ They begin : In Passione Apostolorum. Iussit eum inaumachia cathomis consumi. Cathomis: uirgis nodosis. Hie naumachia forum signat Romanorum quod Prorostris dicitur eo quod rostra, etc.. In Sancto Sebastiano. Saturnus apocatasticus : id est dispositor et destructor fatorum. Annus tuus ex diametro susceptus est. Diametrum est, etc. ‘Glossae collectae’ from the Bible and from Jerome's prefaces come next.

Everyone interested in Latin Etymology knows the last word on mehercle, that the old vocative of meus is prefixed to the old Second Declension form Herclus, Voc. -lě. Without discussing whether this explanation is wholly true or partly wrong, I wish here to disqualify two pieces of evidence. Both originate from a marginal annotation on Rufinus' translation of Eusebius' Church History in, I think, a seventh-century English MS. These marginalia were used for the Leyden Glossary and for the common source (...) of the E E and Corpus Glossaries. The compiler of Leid. transferred them unaltered to his pages; and in the section devoted to Rufinus glosses we find Mehercule: mi fortis. The other compiler often recasts them for dictionary purposes. He gave this item the form Herculus: fortis . But of course the original annotation mi fortis was a mere lucky guess, and the substitution of ‘Herculus’ for Hercules was sheer ignorance. (shrink)

Gellia, of noble lineage, swore she would marry no one lower than a peer, but ultimately flung herself away on—whom? Nupsisti, Gellia, cistifero, say the two best families of MSS.; nupsisti, Gellia, cistibero says the third.

The Teubner edition of Festus de Verborum Significatu had scarcely appeared when Professor Anspach announced his discovery of a MS. of Isidore's Etymologies with some Scholia taken from Festus. Last Easter, in the limited time at my disposal, I transcribed from the MS. the greater part of this Isidore Commentary and, later, received a transcript of the remainder from Abbe Liebaert some weeks before his death. Although hampered by the deficiencies of our University Library, I am unwilling to keep this (...) new evidence any longer from students of Festus. (shrink)

In Italy, at the end of the tenth century, a pedant named Regulus (?) who had a copy of the De Verborum Significatu (or had made extracts from one), wishing to read Plautus (so often quoted by Festus), took the opportunity of an illness to appeal to certain prelates whose church-library contained a MS. of the comedian. Through their stupidity he received not Plautus, but Plato, i.e. Chalcidius' translation of the Timaeus. Disappointed, but not deterred, he wrote the following letter (...) (in a sort of rhyming prose, affected by the litterati of that time) on the fly-leaf and returned the MS. (now Bamberg. Class. 18), hoping that by much repetition he might hammer into their dull heads the difference between PL-AU-TUS and PL-A-TO and yet save them from chagrin and resentment (the material for the letter was supplied by Festus, although the opening illustration comes from Chalcidius). (shrink)

It has been pointed out above that Festus in his quotations cares more for the completion of the line than of the sense. His normal form is one complete line. So the probability is that Liu. Andr. com. is an Iambic Senarius, with a dactyl in the first foot and hiatus at the pause in the sense.

In the Teubner edition, just published, I had to reduce the apparatus criticus to the smallest possible dimensions. All conjectures that were merely probable and not fairly certain had to be excluded. Some of them that are new may find a place here. There is only one MS. of Festus′ epitome of Verrius. It is now at Naples, and is said to have been found in Illyria. Dr. E. A. Loew, the leading authority on Italian script, tells us that it (...) was written at Rome towards the end of the eleventh century. It must have been rescued from a fire; for the outer edges of all the pages are burned away, so that the greater part of the outer of the two columns on each page has been lost. The chief task for editors is to fill up by conjecture these gaps in the outer columns. Scaliger won immortal fame in this work, although many of his conjectures merely followed out a suggestion of his predecessor, Augustini. Ursini and Miiller were of service in adapting to the conditions of space the stop-gaps of Scaliger, and both of them, chiefly Miiller, added excellent conjectures of their own. The conjectural supplements, printed in italics in Müller's edition, have often, especially in German students′ dissertations, been treated as if they were actually part of the text. The Hungarian editor, Emil Thewrewk, who first provided satisfactory manuscript material for Paulus′ epitome of Festus, in order to prevent this error, took the extreme course of omitting these supplements in his edition; although many of them are made absolutely certain by the words of Paulus. I have taken a middle course between Miiller and Thewrewk and have admitted the certain and the probable supplements, leaving blanks elsewhere. The supplements are printed within angular brackets, the merely probable supplements being in italic type. (shrink)

The narrow limits of the apparatus criticus in the new Clarendon Press edition have excluded these suggestions, which may find a place here:I xxix, 4 Quaedam etiam facta sunt ex nominum deriuatione, ut a prudentia ‘prudens ’; quaedam etiam ex uocibus, ut a garrulitate ‘garrulus.’ Although garrulus is the traditional reading, the derivation elsewhere of garrulus from graculus, ‘a jackdaw,’ suggests that we may read here ut a garrulitate ‘graulus.’ For the jackdaw's name in Late Latin developed from gragulus to (...) graulus. (shrink)

Egypt has not yet given us a Greek original of Plautus, unless the paltry Hibeh fragments belong to the original of the Aulularia. If they do, then Plautus departed widely from the Greek. And that is what one would expect. Read any ‘sermo’ in Plautus and see how recklessly he abandons himself to the vagaries of his humour. Clearly no ‘icily regular’ Greek is his guide there. Still a ray of light has come from Egypt that illumines one dark spot (...) in Plautus, the end of the first Scene of the Bacchides. The two sisters retreat into the house after a line which appears in our editions in this form. (shrink)

The wholesome severity of publishers' regulations restricted the small Teubner edition of Festus almost to the actual text of the archetype MSS. of Festus and his epitomator Paulus. The flimsy material to be picked up from mediaeval glossaries was excluded from this small and solid structure and reserved for the ampler space and freer air of a second volume, a volume which should attempt a reconstruction of Festus from Paulus' excerpts, like an antiquarian's reconstruction of the Forum from the ruins (...) that now remain. In Goetz' Corpus Glossariorum Latinorum we have apographs of the chief MS. of each important glossary, and in his Thesaurus Glossarum Emendatarum we have all the glosses edited and arranged in dictionary form; but much spade-work has to be done before these glosses can be used by an editor of Festus. Some has been done already by a pupil of Goetz in a Jena dissertation , who shows the so-called Philoxenus Glossary to be compiled in part from Festus, and collects and emends its Festus glosses. Yet even this piece of work is not complete. For our unique MS. of Philox., a mere ninth-century MS. , is an imperfec record of that large bilingual collection which has left so many traces of itself in the glossaries of the British Isles and of those parts of the Continent which received English or Irish culture. The Ab Absens Glossary, for example, printed by Goetz from a North Frankish MS. of Charlemagne's time, has a number of Festus glosses from this collection which are not recorded in our MS. of Philox. and are accordingly ignored by Dammann. (shrink)

The bilingual Philoxenus Glossary drew some of its materials from Festus de Signif. Verb. and occasionally mentions his name. Its Festus glosses have been collected in a Jena dissertation by Dammann. The Abolita Glossary seems to have begun with Festus excerpts. Before we can glean from these two glossaries every available scrap of evidence about Festus, we must try to complete and correct them. For of the Philoxenus Glossary we have practically only one MS., and that of the ninth century. (...) It must have omitted many items and perverted the words of many others. The Abolita Glossary was associated with another, the Abstrusa Glossary , in Spain, and this composite collection passed into Italy. The MSS. are, we may say, only two, and of each a certain number of leaves are missing. The older and better MS. , an uncial codex of the eighth century, was written apparently in Central Italy; the other was written two centuries later at Monte Cassino. They show us Abol. not in its original form, but rearranged in a not too strict alphabetical order . The St. Gall Glossary was compiled from Philox., the composite Abstr.-Abol., and supplies some of those Festus glosses of Philox. and Abol. which are omitted in our MSS. It seems to have been a Bobbio compilation . Our best MS. was written in rude uncials at St. Gall in the eighth century. (shrink)

In the Phillipps Library at Cheltenham there is a MS. of the Epitome which Professor Thewrewk was unable to use for his edition. No one who knows the difficulties which attend the study of MSS. in this Library will blame him for the omission. The Phillippsianus has the form usual in codices of the Epitome , a quarto volume with two columns to the page, and with each article occupying a separate paragraph and beginning with a fairly large initial letter. (...) It was written by Ellinger , during his previous stay at Altaich, as is shown by the subscription in capital letters which stands at the end of the whole volume, : Abbas indignus ego Ellinger peccator istam glosam scripsi dum essem in Altahensi monasterio Deo sanctoque Quirino. Rogo vos omnes in ea legentes ut oretis pro me. (shrink)

All that we know of this writer comes from an item in the collection of pseudoPlacidus, who, like Nonius Marcellus, collected scholia from MSS. of Republican authors, and with laudable accuracy recorded the exact phrase used by the author as well as the scholium which explains the phrase. The great Latin Thesaurus now makes a practice of distinguishing these valuable items from the worthless Placidus items . A phrase labelled ‘ps.-Plac’ in the Thesaurus may, as a rule, be accepted as (...) the ipsa uevba of a Republican writer; and the next editor of fragments of Republican Dramatists, etc., must bear this in mind. The Oxyrhynchus Papyri enable us to see the kind of MSS., provided with a very few short marginal scholia, from which pseudo-Placidus made his apparently haphazard collection, a collection of which only a part, possibly a very small part, has survived. (shrink)

Terence was studied, though not so much as Virgil, in monastery-schools. Their magistri bestirred themselves to get aid for pupils. Some famous magister— we know not who—had written, between the lines or in the margins, interpretations of difficult words in at least the three opening plays of the MS. which he used—Andr., Ad., Eun.—if not in all. These interpretations were collected from his MS. and found their way into many monastery-libraries. Goetz has published these glossae collectae of Terence from a (...) tenth century MS. in Vol. V. of his Corpus Glossariorum Latinorum, pp. 529–539; Mr. Austin has added more from a Leyden MS. , written apparently in Belgium or Holland, c. 800–815 A.D. . Probably Dr. Theander will add a further batch from a Paris MS. (shrink)